Division of Biology and Medicine
BioMed Core Facilities

Bioimaging Facility

The Leduc Bioimaging Facility provides equipment and training dedicated to high-resolution imaging in the life sciences.

About

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The Leduc Bioimaging Facility, open to all investigators, provides equipment and training dedicated to high-resolution imaging in the life sciences. The facility includes a Cryo Transmission Electron Microscope, a Scanning Electron Microscope, four Fluorescence Microscopes, two automated Slide Scanners, four Confocal Laser Scanning Microscopes, a Multiphoton Microscope, a spinning disk High-Content Screening System, and software for image analysis. The facility also maintains equipment for sample preparation, including a critical point dryer, sputter coater, and microtomes for ultrathin sectioning.

The Bioimaging Facility is a Service Center in the Division of Biology and Medicine and provides microscopes and supporting equipment in Sidney Frank Hall for Life Sciences and the Laboratories for Molecular Medicine.

Learn more about the history of the facility below.

History

The Bioimaging Facility is listed within CoresRI.org, a searchable directory of core facilities in Rhode Island.

CORESRI logo with text that says "a searchable directory of core research facilities, services and instrumentation in Rhode Island"

Services and Instruments

Microscopes in Sidney Frank Hall for Life Sciences

185 Meeting Street: Rooms 105, 106, 107, 109, 111, 113, 115, 117

BMC: Rooms 005

The Thermo Scientific Tundra Cryo-TEM is a 100kV Transmission Electron Microscope for imaging protein structure. It is equipped with a field-emission gun (X-FEG), high-quality lenses, computer-controlled apertures, and a sensitive Falcon C direct detector.
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Microscopes in Laboratories for Molecular Medicine

70 Ship Street: Rooms 111, 133

Service Request and Reservations

Rates

FY25 Rates

ServiceUnitsInternal Academic Rates*External Academic Rates
Confocal
Tundra Cryo (First 4 Hours)Hours$64$101
Tundra Cryo (Additional Hours)Hours$20$31
Olympus FV3000 Confocal MicroscopeHours$52$82
Zeiss LSM 800 ConfocalHours$51$81
Zeiss LSM 880 Confocal (LMM)Hours$51$82
Multiphoton
Olympus FV-1000-MPE Multiphoton MicroscopeHours$62$99
Fluorescence
Nikon Ti2-E High-Content Analysis Fluorescence Microscope (LMM)Hours$31$49
Nikon Ti2-E Widefield Fluorescence Microscope (SFH)Hours$28$44
Zeiss Axiovert 200M Fluorescence Microscope (SFH)Hours$28$44
Electron Microscopy
Apreo VS SEM - (First 4 Hours)Hours$64$102
Apreo VS SEM - (Additional Hours)Hours$18$29
Slide Scanner
Olympus VS200 Slide Scanner (LMM)Hours$40$63
Olympus VS200 Slide Scanner (SFH)Hours$40$64
High Content
Opera Phenix High-Content Screening SystemHours$72$114
Sample Prep
Ultra-microtomeHours$40$64
Critical Point DryerHours$18$29
Sputter CoaterHours$21$34
Diamond KnifeHours$23$37
Pelco BiowaveHours$115$184
Technical Assistance
Technical AssistanceHours$45 
TrainingSession$283$452

*Rates for Brown and Rhode Island Academic and Hospital Affiliates

Effective 11/18/2024

 

Contacts/Location

Microscopist/Facility Manager

Facility Director

The Bioimaging Facility maintains microscopes at the following two locations

The Bioimaging Facility at Sidney Frank Hall
Room 106, 107, 109, 111, 113, 115, 117
185 Meeting Street
Providence, RI 02912

The Bioimaging Facility at the Laboratories for Molecular Medicine
Room 111, 133
70 Ship Street
Providence, RI 02903

Access & Training

The facility largely operates on a self-service model: students, staff and faculty are trained on a specific microscope and can then use the microscope independently. Full-service assistance in microscopy is available. The facility provides training in microscopy, image analysis, and ultrathin sectioning. If you'd like to use one of the microscopes in the facility, you must first schedule training, before signing up on the microscope. 

To schedule a training or request assistance in imaging please contact Geoff Williams.  

To request assistance in sample preparation (e.g. fixation, mounting, sectioning, staining, immunolabeling) and imaging, please contact the Molecular Pathology Core.

Resources for Grants

Acknowledgment

This facility was supported in part by grants from the National Institutes of Health (NIH), Brown University's Division of Biology and Medicine and Provost's office.

* Please acknowledge NIH support.  E.g. in publications that made use of the SEM: 

The Thermo Apreo VS SEM was purchased with a high-end instrumentation grant from the Office of the Director at the National Institutes of Health (S10OD023461). 

The Zeiss 710 Laser Scanning Confocal Microscope was purchased with a high-end instrumentation grant from the Office of the Director at the National Institutes of Health (S10RR023693). 

The Tundra Cryo-TEM was purchased with a high-end instrumentation grant from the Office of the Director at the National Institutes of Health (S10OD032301).