Division of Biology and Medicine
BioMed Core Facilities
Genomics Facility
The Genomics Core Facility provides state-of-the-art genomics equipment and services including Next Generation Sequencing, DNA/RNA shearing, sample QC, Affymetrix microarray, qPCR services as well as other self service instrumentation.
Genomics Facility
The Genomics Core Facility provides state-of-the-art genomics equipment and services including Next Generation Sequencing, DNA/RNA shearing, sample QC, Affymetrix microarray, qPCR services as well as other self service instrumentation.
About
The Genomics Core Facility, located at 70 Ship Street, Room 109, provides state-of-the-art genomics equipment and services to researchers at Brown University, the entire Rhode Island research community and external customers.
The facility offers Next Generation Sequencing, DNA/RNA shearing, sample QC, Affymetrix microarray, qPCR services and provides assistance with experimental design, trouble shooting, and data analysis. Please see our menu for detailed information on the services offered, instruments available and current rates.
The core is available to students, staff and faculty at Brown as well as researchers from all Rhode Island research institutions. Training is provided for new users. We welcome investigators to contact us regarding our services.
Find us at CoresRI!
Services and Instruments
Full-Service Instruments
Our Services
A high throughput bench top sequencer that provides accurate fast sequencing data, and can be easily adopted to a researcher’s needs depending on their required read length and sequencing depth.
We offer analysis of nucleic acid samples (both RNA and DNA) using both the Agilent 2100 Bioanalyzer and Agilent (formerly AATI) Fragment Analyzer.
Molecular barcoding technology for RNA, DNA, and protein profiling applications.
From discovery to translational research, the GeoMx DSP is the most flexible and robust spatial biology solution designed to conform to your ever-changing research needs.
Self-Use Instruments
Instruments Available for Self Use
QuantStudio 6 Pro Real-Time PCR System, 96-well, 0.2 mL block
Provides absolute quantification of target DNA or RNA molecules for EvaGreen or probe-based digital PCR applications.
Access & Training
The Core Facility can be accessed through card access, after authorization. If you don't have a Brown username and password, please contact Christoph Schorl (401-863-2875) for access to the Genomics Core Facility.
Self service is available for trained users after approval by the Facility Director. Affymetrix equipment and bioanalyzer are operated by the director of the Core Facility.
Training by Core Facility staff is required on each instrument before first use. Please contact us to arrange training before you need to use the equipment. Only the Facility's staff members are authorized to train users.
Service Request and Reservations
Please go to iLabs https://brown.ilab.agilent.com/landing/1314 to reserve equipment.
Login with your Brown credentials and select the Genomics core from the drop down menu. Then click on “schedule equipment” and follow the instructions for reservations and billing.
Rates
Equipment User Fees: FY25
| Service | Units | Internal Rates | External Academic Rates |
|---|---|---|---|
| CosMX | Slide | 319 | 509 |
| qPCR (QS6) | Run | $50 | $79 |
| Bio-Rad, Qx200 Digital PCR Reader | Strip | $138 | $221 |
| Nano Drop One | Use | $10 | $16 |
| BioAnalyzer* | Run | $38 | $60 |
| Fragment Analyzer | Run | $53 | $85 |
| Cytation 5 Plate reader / Synergy H1 Hybrid Multimode | Run | $28 | $45 |
| NanoString nCounter Sprint Profiler | Run | $283 | $451 |
| NanoString GeoMX | Slide | $484 | $772 |
| Licor Odyssey System | Run | $8 | $12 |
| Beckman Ultracentrifuge | Hour | $52 | $82 |
| Covaris* | Sample | $20 | $32 |
| Illumina NextSeq 550 Sequencing System - Assisted Use Run/Setup Rate* | Run | $383 | $610 |
| Hourly Labor Rate/Consulting Fee | Hour | $71 | $115 |
Effective 11/18/2024
*Additional variable fees apply for supplies. Please inquire with the Facility Director.
Internal Rates apply to Brown University researchers, Brown University-affiliated researchers (including MBL), and non-profit institutions located in Rhode Island. Commercial rates available, please inquire about prices directly from the Director of the Core Facility (Christoph Schorl, 401-863-2875).
Contacts/Location
Staff
-
Christoph Schorl
70 Ship Street, Room 109
Providence, RI 02912
Contact Address
Genomics Core Facility
Laboratories for Molecular Medicine
Brown University
Box G-E109
Providence, RI 02912
(401) 863-2875
Location
70 Ship Street, Room 109
Providence, RI 02903
Campus Map
Google Maps
Resources for Grants
Genomics Core Facility. This facility is located at the Laboratories of Molecular Medicine and staffed by a full-time PhD-level director. It provides investigators access to a variety of advanced instrumentation and training. DNA sequencing services are provided using an Illumina NextSeq 550 Sequencing System. Instrumentation housed in the facility includes a Nanostring nCounter® SPRINT™ Profiler, an Affymetrix Gene Chip Workstation, two ABI ViiA™ 7 Real-Time PCR Systems, a BIO-RAD QX200 Droplet Digital PCR, an Advanced Analytical Fragment Analyzer, a Cytation 5 Plate Reader, a Synergy H1 Hybrid Multimode (H1MM) Microplate Reader, a Covaris S220 Ultra-Sonicator, an Agilent 2100 Bioanalyzer, a LI-COR Odyssey Infrared Imaging System, a Countess Cell Counter, an AXON GenePix 4000B Scanner, a Beckman Optima Max Ultracentrifuge, and a Nanodrop ND 1000.
Scientific reproducibility is enhanced through scientific rigor and transparency. Scientific rigor is the strict application of the scientific method to ensure unbiased and well-controlled experimental design, methodology, analysis, interpretation, and reporting of results. The Genomics Core is committed to supporting research excellence by adopting the following practices of scientific rigor.
- Purchase and maintain a variety of high-quality instruments from established vendors such that the best instrument is available for any given research analysis.
- The equipment is overseen by highly trained Genomics experts and well maintained under service contracts or funds budgeted for annual preventive maintenance and repairs.
- The Genomics experts are available for experimental design consults or troubleshooting.
- All Genomics users are thoroughly trained by the expert staff, one on one, and not granted access to the instruments until they are deemed to be suitably trained.
- All newly trained users are also required to use the instruments during daytime hours to increase interaction with the expert staff members.
Acknowledgment
This facility has received partial support from the National Institutes of Health (NIGMS grant Number P30GM103410, NCRR grant Numbers P30RR031153, P20RR018728 and S10RR02763), National Science Foundation (EPSCoR grant No 0554548), Lifespan Rhode Island Hospital, Brown University's Division of Biology and Medicine and Provost's office.
If you present work carried out at the Genomics Core Facility in a talk or publication, please remember to acknowledge the Genomics Core facility and its funding.
Please send us the title of your presentation, and where and when you presented the work or the citation for your manuscript.
Thank you very much!