Division of Biology and Medicine
BioMed Core Facilities

Structural Biology Facility

The Structural Biology Core Facility provides state-of-the art equipment for structural modeling in crystals and in solution using X-ray diffraction and scattering as well as magnetic resonance.

About

The Structural Biology Core Facility at Brown University provides state-of-the-art equipment for researchers at Brown University and the surrounding area. Our instruments can be used for structure determination in crystals and in solution, using X-ray diffraction as well as magnetic resonance.

The core facility is equipped with instruments for creating high-resolution biomolecular structural models. We have NMR spectrometers suitable for acquiring high-resolution structural and dynamics data on proteins in the solution state. Additionally, our X-ray source can be used for collecting diffraction data and is equipped to automatically screen up to 80 crystals in a run.

Find us at CoresRI!

CORESRI logo with text that says "a searchable directory of core research facilities, services and instrumentation in Rhode Island

Services and Instruments

NMR Spectrometers

X-ray Instruments

BioPhysics Instruments

Service Request and Reservations

Please go to Brown University iLab
Login with your Brown credentials and select the Structural Biology Core from the drop-down menu. Then click on “schedule equipment” or “request services” and follow the instructions for reservations and billing.

New External and Commercial customers click here

Rates

FY25 Rates

ServiceUnitsInternal Rate*External AcademicCommercial
ASCEND 850 MHz NMRHour$12$20$31
AVANCE III HDTM 600 MHz NMRHour$8$13$21
Avance II Ultrashield  11.7 T 500 MHz NMRHour$5$8$13
Rigaku X-ray SourceHour$27$43$68
Fluoromax -4 SpectrofluorometerHour$13$21$33
Jasco J-815 CD SpectropolarimeterHour$12$20$32
Nanodrop 8000Run$1$1$1
Microcal Isothermal Titration CalorimetryHour$15$24$38
Microcal VPViewer TM CalorimetryHour$11$18$28
Nanotemper MSTHour$20$32$52
Set up/Assistance/TrainingHour$77$123$196

*Rates for Brown and Rhode Island Academic and Hospital Affiliates

Effective as of 11/18/2024

Contact/Location

Facility Manager

Facility Director

Laboratory Address

Structural Biology Core Facility
Laboratories for Molecular Medicine
70 Ship Street, Floor 1
Providence, RI 02903

Directions

Directions to the Structural Biology Core Facility

Equipment Resources

The BMRB is a repository of NMR data and also aggregates this data for purposes of comparison and study.

C6 at CSIRO is a tool for comparing crystallization conditions across many different kinds of screens. This may help develop a screening strategy.

The PDB is a repository for biomolecular structures.

Resources for Grants

Publications

Read about the science being performed at Brown University's Structural Biology Core Facility.

The high-field magnets housed in the Structural Biology Core Facility were used to collect all of the experimental data presented in these publications. In these reports, NMR spectroscopy uncovered mechanistic signatures, both structural and dynamic, that led to new insight regarding the propagation of biomolecular signals in a diverse set of enzymes.

Acknowledgment

This facility was supported in part by Brown University's Division of Biology and Medicine and Provost's office.

We ask that researchers collecting data at the facility acknowledge its use as follows:

This research is based in part on data obtained at the Brown University Structural Biology Core Facility, which is supported by the Division of Biology and Medicine, Brown University.