Structural Biology Facility
The Structural Biology Core Facility provides state-of-the art equipment for structural modeling in crystals and in solution using X-ray diffraction and scattering as well as magnetic resonance.
Structural Biology Facility
The Structural Biology Core Facility provides state-of-the art equipment for structural modeling in crystals and in solution using X-ray diffraction and scattering as well as magnetic resonance.
About
The Structural Biology Core Facility at Brown University provides state-of-the-art equipment for researchers at Brown University and the surrounding area. Our instruments can be used for structure determination in crystals and in solution, using X-ray diffraction as well as magnetic resonance.
The core facility is equipped with instruments for creating high-resolution biomolecular structural models. We have NMR spectrometers suitable for acquiring high-resolution structural and dynamics data on proteins in the solution state. Additionally, our X-ray source can be used for collecting diffraction data and is equipped to automatically screen up to 80 crystals in a run.
Find us at CoresRI!
Services and Instruments
NMR Spectrometers
X-ray Instruments
BioPhysics Instruments
Service Request and Reservations
Please go to Brown University iLab
Login with your Brown credentials and select the Structural Biology Core from the drop-down menu. Then click on “schedule equipment” or “request services” and follow the instructions for reservations and billing.
New External and Commercial customers click here
Rates
FY25 Rates
Service | Units | Internal Rate* | External Academic | Commercial |
---|---|---|---|---|
ASCEND 850 MHz NMR | Hour | $12 | $20 | $31 |
AVANCE III HDTM 600 MHz NMR | Hour | $8 | $13 | $21 |
Avance II Ultrashield 11.7 T 500 MHz NMR | Hour | $5 | $8 | $13 |
Rigaku X-ray Source | Hour | $27 | $43 | $68 |
Fluoromax -4 Spectrofluorometer | Hour | $13 | $21 | $33 |
Jasco J-815 CD Spectropolarimeter | Hour | $12 | $20 | $32 |
Nanodrop 8000 | Run | $1 | $1 | $1 |
Microcal Isothermal Titration Calorimetry | Hour | $15 | $24 | $38 |
Microcal VPViewer TM Calorimetry | Hour | $11 | $18 | $28 |
Nanotemper MST | Hour | $20 | $32 | $52 |
Set up/Assistance/Training | Hour | $77 | $123 | $196 |
*Rates for Brown and Rhode Island Academic and Hospital Affiliates
Effective as of 11/18/2024
Contact/Location
Facility Manager
Facility Director
Laboratory Address
Structural Biology Core Facility
Laboratories for Molecular Medicine
70 Ship Street, Floor 1
Providence, RI 02903
Directions
Equipment Resources
The BMRB is a repository of NMR data and also aggregates this data for purposes of comparison and study.
C6 at CSIRO is a tool for comparing crystallization conditions across many different kinds of screens. This may help develop a screening strategy.
The PDB is a repository for biomolecular structures.
Resources for Grants
Publications
Read about the science being performed at Brown University's Structural Biology Core Facility.
The high-field magnets housed in the Structural Biology Core Facility were used to collect all of the experimental data presented in these publications. In these reports, NMR spectroscopy uncovered mechanistic signatures, both structural and dynamic, that led to new insight regarding the propagation of biomolecular signals in a diverse set of enzymes.
Acknowledgment
This facility was supported in part by Brown University's Division of Biology and Medicine and Provost's office.
We ask that researchers collecting data at the facility acknowledge its use as follows:
This research is based in part on data obtained at the Brown University Structural Biology Core Facility, which is supported by the Division of Biology and Medicine, Brown University.