Division of Biology and Medicine
BioMed Core Facilities

500 MHz Bruker Avance II

Our ultra-shielded 500 MHz spectrometer operates with a room-temperature TXI z-gradient probe with automatic tuning and matching capability. The instrument is controlled using Topspin 3.1.

Methods Library

Chemical Exchange

Wang C, Rance M, Palmer AG III. "Mapping chemical exchange in proteins with MW > 50 kD." J Am. Chem. Soc. 2003 (125): p 8968-9. DOI: 10.1021/ja035139z

Kneller JM, Lu M, and Bracken C. "An effective method for the discrimination of motional anisotropy and chemical exchange". J. Am. Chem. Soc. 2002 (124): p 1852-3. DOI: 10.1021/ja017461k

Dynamics Models

Lipari G and Szabo A. "Model-free approach to the interpretation of nuclear magnetic resonance relaxation in macromolecules. 1. Theory and range of validity".  J. Am. Chem. Soc. 1982 (104): p 4546-4559. DOI: 10.1021/ja00381a009